Griphen ® Adult
Adult cold
Scored Tablet
Category:
Antihistaminic (H1 –receptor)-decongestant-analgesic.
(USP DI)
Chemistry:
Acetaminophen:N-(4-hydroxyphenyl)acetamide
.weight:151.16 g/mol.formula: C8H9NO2. Phenylephrine hydrochloride:3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride,weight:
203.66g/mol,formula:C9H14ClNO2 .
Chlorpheniramine Maleate:(Z)-but-2-enedioic
acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine ,weight:390.9
g/mol,formula:C20H23ClN2O4 .
|
PHENYLEPHRINE HYDROCHLORIDE Acetaminophen
Chlorpheniramine Maleate
(pubchem.ncbi.gov)
|
Pharmacokinetics:
-Acetaminophen: The plasma half-life:. 1.25-3 hours, elimination: renally, the systemic availability is subject to first
– pass metabolism (70 -90%).
-Chlorpheniramine:well absorbed,metabolism:extensive and
rapid(gastricmucosa and liver)elimination: in the urine, Plasma half-life:2-4 hours, Terminal elimination
half-life (healthy adults and children): 20-24 hours and 10-13 hours,
respectively.
-Phenylephrine: it has reduced
bioavailability by the oral route due to first – pass metabolism, The pharmacologic effect of phenylephrine is
terminated at least in part by uptake of the drug into tissues.
(PDR.net)
Indications:
For treatment of Cold symptoms,Congestion(nasal
and Sinus).
(USP DI)
Contraindications:
-This tablet should not be used concurrently
with Monoamine Oxidase Inhibitors (MAOIs) or within 2 weeks of discontinuing
MAOI therapy.
-It should not be use with alcoholic
beverages , head trauma and increased intracranial pressure, Asthma,
bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, status asthmaticus,
tobacco smoking, hepatic disease, Renal disease, Acute myocardial infarction,
angina, arteriosclerosis, cardiac arrhythmias, cardiac disease.
-If there is any sensivity to any of the
medications in combination being taken.
(PDR.net)
Warnings and precautions:
-It should be use with caution in patients
with Raynaud's phenomenon or diabetes mellitus, prostatic
hypertrophy,closed angle glaucoma.
-Avoid driving or operating machinery until
you know how this product will affect you.
-Avoid use in children <12 years of age.
(medicine.org.uk)
Pregnancy:
The use should be limited to short-term under
the supervision of qualified health –care professional. only if the potential
benefits are greater than the risks.
(PDR.net)
Breast – Feeding:
It should be
avoided if possible during breast-feeding.
(PDR.net)
Drug Interactions
CNS depressants or stimulates, alcohol,anticholinergics,
medicine for high blood pressure.
(USP DI)
Adverse
reactions:
Especially allergic reactions,anticholinergic
effects(excessive sedation,confusion,dry month,constipation,urinary retention),blood
dyscrasias,jaundice,dizziness,palpitations.
(USP DI, PDR.net)
Overdosage:
Suspected overdose:Getting emergency help at
once.
(USP DI)
Dosage and Administration:
Adults:1 or 2 Tablets every 6 hours if needed
and don, t use more than 8 Tablets in 24 hours.
Children:it should Prescribe by the physician.
(USP DI)
Storage:
Store below 30
and away from heat & direct light,keep out of sight of the children.
How Supplied:
Griphen ® Adult tablets (325 mg Acetaminophen , 5 mg Phenylephrine Hcl , 2 mg Chlorpheniramine
maleate) are availabele at blisters of 10's in a box of 30 and 100 with leaflet.
Reference:
1- (PDR.net),2020 2- (medicine.org.uk),2020 3- (pubchem.ncbi.gov),2020 4- (USP DI),2007